preprints_ui: g2nvs_v1
Data license: ODbL (database) & original licenses (content) · Data source: Open Science Framework
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| g2nvs_v1 | Cellulite reduction by Varipads® compression technology is superior to compression alone, improves quality of life, and reduces local lymph in tissues – results of a ‘split-side’ comparison trial. | Aims: Cellulite affects most adult women and has a cosmetic and psychological impact. Previous work has shown compression garments with Varipads® significantly improves the appearance of cellulite. However, that trial did not distinguish between the effect solely due to compression and that due to Varipads®. The aim of this trial was to identify any additional benefit due to Varipads® over and above compression alone. Methods: 62 biological women (mean 48 years – range 19–67) with cellulite were recruited. We specifically recruited in the following sizes: 10 small (UK Dress 8-10), 20 medium (UK Dress 12-14), 20 large (UK Dress 16-18), and 10 extra-large (UK Dress 20 – 22). Compression garments covered from waist to mid-thigh, with Varipads® on the left and plain compression on the right. Garments were worn for 8 hours in each 24, daily, for 6 months. Primary endpoint – subjects reporting a difference between the sides and asking for a garment with Varipads® bilaterally. Secondary endpoints were changes in quality of life (QoL) (Celluqol®) and transdermal water content (TDWC) (Lymphscanner®). Results: 42 (68%) subjects completed the 6-months trial. 32 of 42 (76%) saw a difference between the sides within the 6 months of the trial. Of these 23 (72%) saw the difference within 3 months, and 9 (28%) between 3 and 6 months. Overall, there was a significant improvement of QoL and reduction in TDWC. Subjectively, the most common comment was that the skin on the Varipads® side felt smoother and more toned. Conclusion: The addition of Varipads® to a compression garment that covers the buttocks and upper thighs, improves the appearance of cellulite in 76% of subjects compared to compression alone. Furthermore, compression with Varipads® both significantly improves QoL and reduces TDWC. This suggests that compression with Varipads® reduces the appearance of cellulite by stimulating local lymphatic return from the superficial tissues. | 2024-09-25T12:59:20.975121 | 2024-09-26T08:51:41.015968 | 2024-09-26T08:51:30.590917 | coppreprints | 1 | accepted | 1 | 1 | https://doi.org/10.31219/osf.io/g2nvs | CC0 1.0 Universal | Cellulite; QoL; Varipads; compression; quality of life | ["Cellulite", "QoL", "Varipads", "compression", "quality of life"] | Ashleigh Poulsen; Sarah S Duro; Mark Steven Whiteley | [{"id": "sz8dh", "name": "Ashleigh Poulsen", "index": 0, "orcid": null, "bibliographic": true}, {"id": "agp8t", "name": "Sarah S Duro", "index": 1, "orcid": null, "bibliographic": true}, {"id": "bp75e", "name": "Mark Steven Whiteley", "index": 2, "orcid": "0000-0001-6727-6245", "bibliographic": true}] | Ashleigh Poulsen | Compression; General Subjects and Opinions | [{"id": "63bc4af60a7f38410b2ca077", "text": "Compression"}, {"id": "644ac7030a7f380cbbae49e8", "text": "General Subjects and Opinions"}] | https://osf.io/download/66f40932beb218e4343cba53 | 1 | Mark Whiteley is a shareholder and director of Coria Ltd. which owns the IP for the Varipads® compression system. | no | available | ["https://cdn.clinicaltrials.gov/large-docs/81/NCT05959681/Prot_ICF_000.pdf"] | prereg_designs | 2025-04-09T21:06:16.724318 |