preprints_ui: smkvq_v1
Data license: ODbL (database) & original licenses (content) · Data source: Open Science Framework
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| smkvq_v1 | Repositioning vitamin C as a promising option for alleviating the complications associated with COVID-19 | Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to antiviral function. Numerous evidence suggests that vitamin C fights off inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance immune system makes this vitamin a prospective therapeutic agent amid the current situation of COVID-19. Being highly effective against influenza virus causing common cold, vitamin C can also function against SARS-CoV-2, the causal agent of COVID-19. Severe infections need higher doses of the vitamin to compensate for the augmented inflammatory response and metabolic demand that commonly occur during COVID-19. Compelling evidence also suggests that a high dose of vitamin C (1.5 g/kg body weight) in inflammatory conditions can result in effective clinical outcomes and thus can be employed to combat COVID-19. However, further studies are crucial to delineate the underlying mechanism of vitamin C action against COVID-19. The current effort was aimed at repositioning vitamin C for developing a novel approach for alleviating COVID-19-associated complications. | 2020-07-14T08:08:30.971876 | 2020-07-14T14:54:50.307610 | 2020-07-14T08:13:44.005045 | marxiv | 0 | withdrawn | 1 | 1 | https://doi.org/10.31230/osf.io/smkvq | CC-By Attribution-ShareAlike 4.0 International | Autophagy; COVID-19; Immune response; Inflammation; Oxidative stress; SARS-CoV-2; Vitamin C | ["Autophagy", "COVID-19", "Immune response", "Inflammation", "Oxidative stress", "SARS-CoV-2", "Vitamin C"] | Mithila Farjana; Akhi Moni; Abdullah Al Mamun Sohag; Adeba Hasan; Md. Abdul Hannan; Md. Golzar Hossain; Md Jamal Uddin | [{"id": "qzy8a", "name": "Mithila Farjana", "index": 0, "orcid": "0000-0002-8145-7066", "bibliographic": true}, {"id": "r5wn4", "name": "Akhi Moni", "index": 1, "orcid": null, "bibliographic": true}, {"id": "4sqeh", "name": "Abdullah Al Mamun Sohag", "index": 2, "orcid": null, "bibliographic": true}, {"id": "qat8x", "name": "Adeba Hasan", "index": 3, "orcid": null, "bibliographic": true}, {"id": "g24mt", "name": "Md. Abdul Hannan", "index": 4, "orcid": null, "bibliographic": true}, {"id": "4vkna", "name": "Md. Golzar Hossain", "index": 5, "orcid": null, "bibliographic": true}, {"id": "tbvnx", "name": "Md Jamal Uddin", "index": 6, "orcid": "0000-0003-2911-3255", "bibliographic": true}] | Mithila Farjana | Life Sciences; Biology; Integrative Biology | [{"id": "59fcb37854be8102f2532513", "text": "Life Sciences"}, {"id": "59fcb37854be8102f253251c", "text": "Biology"}, {"id": "59fcb37954be8102f2532526", "text": "Integrative Biology"}] | 0 | not_applicable | null | 2025-04-09T20:04:07.807492 |