preprints_ui: uy9be_v1
Data license: ODbL (database) & original licenses (content) · Data source: Open Science Framework
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| uy9be_v1 | Focused ultrasound and immunotherapy for melanoma brain metastases | Using a “two-site” model of melanoma, determine the experimental therapeutic efficacy (i.e. tumor growth control, improved survival, and CD8 T cell recruitment) of αCD40 administration against extracranial and intracranial tumors. Determine whether enhancing delivery of αCD40 to the intracranial tumor via BTB opening with FUS and MBs enhances experimental therapeutic efficacy (i.e. tumor growth control, improved survival, and CD8 T cell recruitment). Determine whether thermal ablation of the extracranial tumor in the presence of αCD40 enhances experimental therapeutic efficacy for one or both tumors (i.e. tumor growth control, improved survival, and CD8 T cell recruitment). Determine whether, in the context of thermal ablation of the extracranial tumor + αCD40, BTB opening with FUS and MBs enhances experimental therapeutic efficacy in the intracranial tumor (i.e. tumor growth control, improved survival, and CD8 T cell recruitment). | 2024-10-30T18:31:24.024299 | 2024-10-30T18:36:26.592285 | 2024-10-30T18:32:53.318095 | focusarchive | 1 | accepted | 1 | 1 | https://doi.org/10.31225/osf.io/uy9be | CC-By Attribution 4.0 International | [] | Richard J Price; Vinton WT Cheng | [{"id": "xsk3r", "name": "Kelsie Timbie", "index": 0, "orcid": null, "bibliographic": false}, {"id": "gesu4", "name": "Richard J Price", "index": 1, "orcid": null, "bibliographic": true}, {"id": "xykt2", "name": "Vinton WT Cheng", "index": 2, "orcid": null, "bibliographic": true}] | Kelsie Timbie | Medicine and Health Sciences | [{"id": "59bacc5654be81033c4e4a6d", "text": "Medicine and Health Sciences"}] | https://osf.io/download/67227b85a9f0e913a51de374 | 0 | no | not_applicable | [] | 2025-04-09T21:06:19.363964 |