preprints_ui: wm7yt_v1
Data license: ODbL (database) & original licenses (content) · Data source: Open Science Framework
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| wm7yt_v1 | Investigation of low-intensity focused ultrasound for human pain management | The insula is an intriguing target for pain modulation. Unfortunately, it lies deep to the cortex making spatially specific noninvasive access difficult. Here, we leverage the high spatial resolution and deep penetration depth of low-intensity focused ultrasound (LIFU) to non-surgically modulate the anterior insula (AI) or posterior insula (PI) in humans for effect on subjective pain ratings, electroencephalographic (EEG) contact heat–evoked potentials, as well as autonomic measures including heart-rate variability (HRV). We also test and offline protocol to determined the longevity of effects on the CHEP and pain intensity | 2024-05-20T16:26:45.845811 | 2024-05-22T17:52:01.385403 | 2024-05-22T17:51:28.981271 | 2024-05-01T04:00:00 | https://doi.org/10.1097/j.pain.0000000000003171 | focusarchive | 1 | accepted | 1 | 1 | https://doi.org/10.31225/osf.io/wm7yt | CC-By Attribution 4.0 International | Low intensity focused ultrasound; human; neuromodulation; pain | ["Low intensity focused ultrasound", "human", "neuromodulation", "pain"] | wynn legon | [{"id": "czs92", "name": "wynn legon", "index": 0, "orcid": "0000-0002-8761-3496", "bibliographic": true}] | wynn legon | Medicine and Health Sciences; Translational Medical Research | [{"id": "59bacc5654be81033c4e4a6d", "text": "Medicine and Health Sciences"}, {"id": "59bacc5654be81033c4e4a79", "text": "Translational Medical Research"}] | https://osf.io/download/664b79c92f167d124a0e7b93 | 0 | no | no | [] | 2025-04-09T20:49:46.414328 |